Cinnarizine therapy: a new concept in prevention of experimental dilating cardiomyopathy

This work was undertaken to investigate the role of cinnarizine, a potent vasodilator with a property of calcium entry blocker in ameliorating the cardiomyopathic lesion induced by cobalt and adriamycin toxicity. Cobalt 20mg. Kg[-1]or adriamycin 50mg. Kg[-1] have been injected intra-peritonealy twice weekly in rats treated with cinnarizine 2mg.Kg[-1] intra-peritonealy. The results showed that cobalt or adriamycin induced cardiomegaly. The associated alteration in haemoglobin level and red blood corpuscles count as well as the histopathology of heart were modified when cinnarizine injected simultaneously with cobalt or adriamycin